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Updated: Jan 21, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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Tumor mutation burden: from comprehensive mutational screening to the clinic

Francesca Galuppini1, Carlo Alberto Dal Pozzo1, Jutta Deckert2

  • 11Department of Medicine, Surgical Pathology Unit, University of Padua, Via Aristide Gabelli, 61, 35121 Padua, Italy.

Cancer Cell International
|August 14, 2019
PubMed
Summary

Tumor Mutational Burden (TMB) shows promise as a predictive biomarker for immunotherapy response in carcinomas. While next-generation sequencing facilitates TMB analysis, cost and expertise hinder its routine diagnostic use.

Keywords:
ImmunotherapyNext generation sequencingTarget therapyTumor mutation burden

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