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Hypotensive episodes associated with azithromycin infusion: a potentially fatal adverse drug reaction

Jeffrey Wong1, Maitri Munsif1, Robyn O'Hehir1

  • 1Department of Respiratory Medicine The Alfred Hospital Melbourne Victoria Australia.

Respirology Case Reports
|August 14, 2019
PubMed

Insights

Hypotension, a dangerous adverse drug reaction (ADR), can occur with intravenous azithromycin. Promptly stopping the azithromycin infusion successfully managed this potentially fatal event.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Adverse Drug Reactions

Background:

  • Azithromycin is a widely used antibiotic globally.
  • Intravenous administration of azithromycin is common in clinical practice.
  • Awareness of potential adverse drug reactions is crucial for patient safety.

Observation:

  • A case of severe hypotension was observed during intravenous azithromycin infusion.
  • The hypotensive episodes presented as a potentially fatal adverse drug reaction.
  • Immediate cessation of the azithromycin infusion was implemented.

Findings:

  • The patient experienced hypotensive episodes directly linked to intravenous azithromycin.
  • The adverse drug reaction (ADR) carried a risk of irreversible end-organ damage.
  • Successful management was achieved by discontinuing the azithromycin infusion.

Implications:

  • Clinicians must be vigilant for this rare but serious azithromycin ADR.
  • Prompt recognition and management of azithromycin-induced hypotension are critical.
  • This case highlights the importance of monitoring patients receiving intravenous azithromycin.
Keywords:
Antibioticsazithromycinhypotensionpneumonia

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