Related Experiment Video
Updated: Jan 21, 2026

Experimental Model of Ligature-Induced Peri-Implantitis in Mice
Published on: May 17, 2024
Restorative design and associated risks for peri-implant diseases
Douglas R Dixon1, Robert M London1
1University of Washington, Seattle, Washington, USA.
Abstract:
The prevalence of inflammatory conditions around dental implants is significant. Current analysis indicates that the rates for peri-mucositis and peri-implantitis may be as high as 40%-65% and 20%-47%, respectively. Over the last decade, many risk factors have been associated with peri-mucositis and peri-implantitis, creating a multifactorial disease etiology that complicates both diagnosis and treatment. Furthermore, additional considerations such as initial surgical implant placement position, disruption of the biologic interface associated with the implant-abutment interface manipulation, or prosthetic design may also influence the host response to commonly employed oral prostheses or the diagnosis of inflammatory states. Coupled with the temporal nature of disease progression around implants, understanding and accounting for these additional parameters may help reduce the number of variables that the surgeon/restorative team face when incorporating implant therapy into daily practice. Therefore, this review discusses the importance of surgical and restorative design by reviewing the concepts of natural and prosthetic emergence profile and implant design and position, as well as many other restorative concepts related to potential implant complications and disease. Understanding both the inflammatory nature of peri-implant disease and additional parameters related to both surgical and prosthetic procedures may provide the best possible approach to reducing the prevalence of both peri-mucositis and peri-implantitis within the realm of dental implant therapy.
Related Concept Videos
Restorative Care
Design Example: Analyzing Capacity Contours for Flood Risk Assessment
Group Design
Relative Risk
Factorial Design
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

