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Related Experiment Video

Updated: Jan 21, 2026

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
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Myocardial-Infarction-Responsive Smart Hydrogels Targeting Matrix Metalloproteinase for On-Demand Growth Factor

Caixia Fan1, Jiajia Shi1,2, Yan Zhuang1

  • 1Key Laboratory for Nano-Bio Interface Research, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.

Advanced Materials (Deerfield Beach, Fla.)
|August 14, 2019
PubMed
Summary

A novel hydrogel delivers growth factors on demand after myocardial infarction (MI). This targeted therapy promotes blood vessel growth and reduces cardiac damage, offering a promising treatment for heart disease.

Keywords:
basic fibroblast growth factorhydrogelsmatrix metalloproteinasesmicroenvironment responsemyocardial infarction

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A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
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Area of Science:

  • Biomaterials Science
  • Cardiovascular Research
  • Drug Delivery Systems

Background:

  • Myocardial infarction (MI) treatment faces challenges with local drug delivery, leading to low efficacy and toxicity.
  • Restoring blood supply and managing extracellular matrix degradation are key therapeutic goals post-MI.
  • Targeting matrix metalloproteinases (MMPs) is crucial for inhibiting adverse cardiac remodeling.

Purpose of the Study:

  • To develop a dual-functional, MI-responsive hydrogel for on-demand therapeutic delivery.
  • To promote angiogenesis and inhibit cardiac remodeling by targeting MMP-2/9.
  • To overcome limitations of local drug delivery in myocardial infarction treatment.

Main Methods:

  • Fabrication of a glutathione (GSH)-modified collagen hydrogel (collagen-GSH).
  • Preparation of a recombinant protein GST-TIMP-bFGF, incorporating bFGF, GST, and an MMP-cleavable peptide.
  • Utilizing specific GST-GSH binding for enhanced drug loading and MMP-triggered release.

Main Results:

  • The GST-GSH interaction significantly increased GST-TIMP-bFGF loading in the hydrogel.
  • The hydrogel demonstrated on-demand release of bFGF in response to MMPs.
  • Treatment with GST-TIMP-bFGF/collagen-GSH hydrogels improved vascularization and reduced cardiac remodeling in MI rats.

Conclusions:

  • On-demand growth factor delivery via responsive hydrogels is effective for MI treatment.
  • Synchronized control of binding and release promotes angiogenesis and attenuates cardiac remodeling.
  • This approach shows promise for treating ischemic heart disease.