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Updated: Jan 21, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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Alteration of Physicochemical Properties for Antibody-Drug Conjugates and Their Impact on Stability

Jakob W Buecheler1, Matthias Winzer2, Christian Weber2

  • 1Division of Pharmaceutics, Friedrich-Alexander University (FAU) Erlangen-Nuernberg, Freeze Drying Focus Group, 91058 Erlangen, Germany; Merck Healthcare KGaA, Discovery and Development Technologies, 64293 Darmstadt, Germany.

Journal of Pharmaceutical Sciences
|August 14, 2019
PubMed

Keywords:
antibody-drug conjugate(s) (ADC)conjugationprotein aggregationprotein structureself-associationstability

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