Related Experiment Video

Updated: Jan 21, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

11.1K

Altered microRNA processing proteins in HPV-induced cancers

Barbara C Snoek1, Iris Babion1, Danijela Koppers-Lalic2

  • 1Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, Netherlands.

Current Opinion in Virology
|August 14, 2019
PubMed

Insights

High-risk human papilloma virus (hrHPV) infections drive cancer. Deregulated miRNA processing proteins and their variants (isomiRs) may be key in early cancer development and diagnosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Virology

Background:

  • High-risk human papilloma virus (hrHPV) infections are linked to anogenital and head and neck cancers.
  • MicroRNAs (miRNAs) and their variants (isomiRs) are implicated in the development and progression of HPV-induced malignancies.
  • Specific miRNA processing proteins, including Drosha, AGO2, and TENT2, show deregulation in HPV-related cancers.

Purpose of the Study:

  • To investigate the role of miRNA processing proteins and their generated isomiRs in the early stages of HPV-induced cancer development.
  • To explore the potential of isomiRs as biomarkers for early cancer diagnosis.

Main Methods:

  • Analysis of miRNA processing protein deregulation in HPV-induced cancers.
  • Characterization of isomiR profiles in precancerous and cancerous lesions.
  • Correlation of protein deregulation with isomiR generation and cancer progression.

Main Results:

  • Deregulation of key miRNA processing proteins (Drosha, AGO2, TENT2) observed in HPV-induced cancers, even at precancerous stages.
  • Evidence suggests these proteins are involved in early cancer development.
  • Generated isomiRs show potential as biomarkers for early cancer detection.

Conclusions:

  • MiRNA processing proteins play a significant role in the early development of HPV-related cancers.
  • IsomiRs represent promising biomarkers for the early diagnosis of HPV-associated malignancies.
  • Targeting miRNA processing pathways could offer novel therapeutic strategies.

More Related Videos

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.7K
Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

354

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.0K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.8K
Alterations in Respiration II01:30

Alterations in Respiration II

There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.7K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
6.9K
Altered States of Awareness01:06

Altered States of Awareness

Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.0K
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.1K