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Transient receptor potential ankyrin 1 (TRPA1)-mediated toxicity: friend or foe?

Mohaddeseh Sadat Alavi1, Ali Shamsizadeh2, Gholamreza Karimi3,4

  • 1Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Toxicology Mechanisms and Methods
|August 15, 2019
PubMed

Insights

Transient receptor potential ankyrin 1 (TRPA1) channels are implicated in various toxicities. TRPA1 antagonists show promise for treating toxic reactions and adverse drug effects.

Area of Science:

  • Toxicology
  • Molecular Biology
  • Pharmacology

Background:

  • Transient receptor potential (TRP) channels are crucial in sensing environmental stimuli.
  • TRPA1 channels are widely distributed and involved in pain, cold, and damage sensation.
  • TRPA1's role in physiological and pathological conditions necessitates understanding its toxicological implications.

Purpose of the Study:

  • To review recent studies on the role of TRPA1 in various toxicities.
  • To categorize TRPA1's involvement in neurotoxicity, cardiotoxicity, dermatotoxicity, and pulmonary toxicity.
  • To highlight the potential of TRPA1 antagonists in managing toxic effects.

Main Methods:

  • Literature review of recent studies on TRPA1 and toxicology.
  • Categorization of toxic compounds and materials mediated by TRPA1.
  • Analysis of the efficacy and safety of TRPA1 antagonists.

Main Results:

  • TRPA1 mediates toxicity induced by acetaminophen, heavy metals, tear gases, chemotherapeutics, acrolein, particulate matter, cigarette smoke, and sulfur mustard.
  • TRPA1 plays a role in neurotoxicity, cardiotoxicity, dermatotoxicity, and pulmonary toxicity.
  • TRPA1 antagonists demonstrate safety and efficacy in resolving specific toxicities.

Conclusions:

  • TRPA1 is a significant mediator of toxicity for a wide range of chemical and environmental agents.
  • TRPA1 antagonists represent a promising therapeutic strategy for mitigating diverse toxicological insults.
  • Targeting TRPA1 offers a potential avenue for managing adverse drug reactions and environmental exposures.
Keywords:
TRPA1coldneurotoxicitypainrespiratory systemtoxicology

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