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Related Experiment Video

Updated: Jan 20, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

Association between tumor location and neurocognitive functioning using tumor localization maps.

Esther J J Habets¹, Eef J Hendriks², Martin J B Taphoorn^3,4

¹Department of Neurology, Haaglanden Medical Center, Lijnbaan 32, PO BOX 432, The Hague, 2501 CK, The Netherlands. e.habets@haaglandenmc.nl.

Journal of Neuro-Oncology

|August 15, 2019

Summary

Diffuse glioma patients often have preoperative neurocognitive impairment. Left hemisphere tumors pose the highest risk for attention and working memory deficits, impacting surgical planning and rehabilitation.

Keywords:

Functional mapping Glioma MRI Neurocognitive functioning

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Published on: March 25, 2020

Area of Science:

Neuroscience
Neurosurgery
Cognitive Psychology

Background:

Diffuse glioma patients frequently exhibit neurocognitive impairment before surgery.
Understanding the link between tumor location and cognitive deficits is crucial for clinical decisions.
Brain lesion location and function relationships offer unique insights into cognitive processes.

Purpose of the Study:

To investigate the impact of tumor location on preoperative neurocognitive functioning (NCF) in diffuse glioma patients.
To identify specific brain regions associated with NCF deficits using MRI-based lesion-symptom mapping.

Main Methods:

Seventy-two patients with suspected gliomas were analyzed preoperatively.
Voxel-based lesion-symptom mapping was employed to correlate tumor location with NCF.
Six cognitive domains were assessed to evaluate preoperative neurocognitive functioning.

Main Results:

Preoperative NCF was significantly impaired across all tested domains compared to controls.
Attention deficits (30%) and working memory deficits (20%) were most prevalent.
Attention deficits were linked to left frontoparietal regions and subcortical tracts; working memory deficits showed no specific regional association.

Conclusions:

Patients with left hemisphere diffuse gliomas face the highest risk of preoperative NCF deficits.
A left frontoparietal network is implicated in NCF, informing surgical strategies and patient counseling.
Findings can guide optimized surgical procedures and cognitive rehabilitation for glioma patients.