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Updated: Jan 20, 2026

Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
Plasma ghrelin levels after laparoscopic sleeve gastrectomy in obese individuals
Garima Sharma1, Prabhdeep S Nain2, Pulkit Sethi3
1Department of Physiology, Dayanand Medical College & Hospital, Ludhiana, India.
Background & Objectives:
Ghrelin is an orexigenic gut hormone expressed by the gastric fundus. Laparoscopic sleeve gastrectomy (LSG) procedure involves resection of the gastric fundus leading to a decreased appetite and weight loss. This study was undertaken to determine the levels of plasma ghrelin after sleeve gastrectomy in obese patients.
Methods:
The study was conducted on 90 morbidly obese patients [body mass index (BMI) >40 kg/m[2]] and severely obese patients (BMI >35/kg/m[2]) who underwent sleeve gastrectomy. The patients were followed up for six months. Weight loss parameters and plasma ghrelin levels were assessed pre- and postoperatively.
Results:
A significant weight loss and decrease in BMI were observed at three and six months postoperatively. A significant decrease in plasma ghrelin levels over six months of follow up postoperatively was also seen.
Interpretation & Conclusions:
These preliminary findings indicated inhibition of ghrelin production after LSG leading to a decrease in the plasma ghrelin levels within a few days of surgery and sustainable weight loss in obese patients.
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