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Updated: Jan 20, 2026

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
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Intravitreal dexamethasone implants for non-infectious uveitis.

Matthew McCartney1,2, Peter McCluskey3,4, Sophia Zagora3,4

  • 1Department of General Surgery, St Vincent's Hospital, Sydney, Victoria, Australia.

Clinical & Experimental Ophthalmology
|August 15, 2019
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Summary

Dexamethasone (DEX) implants effectively reduced cystoid macular edema and improved vision in non-infectious uveitis patients. This localized therapy also significantly decreased the need for systemic corticosteroids.

Keywords:
Ozurdexdexamethasone implantintermediate uveitisnon-infectious uveitisuveitis

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Uveitis Management

Background:

  • Cystoid macular edema (CMO) from non-infectious uveitis (NIU) threatens vision.
  • Corticosteroids are standard treatment, but localized therapy offers advantages.
  • Sustained-release dexamethasone (DEX) implants provide localized corticosteroid delivery.

Purpose of the Study:

  • To evaluate the efficacy of DEX implants in an Australian cohort of NIU patients.
  • To assess the impact of DEX implants on central retinal thickness (CRT) and visual acuity.
  • To determine the effect of DEX implants on systemic corticosteroid use.

Main Methods:

  • Retrospective case series of 20 eyes from 17 NIU patients treated with DEX implants.
  • Data collected from March 2012 to March 2018 at a tertiary eye hospital.
  • Primary outcome: >20% CRT reduction at two consecutive visits; Secondary outcomes: best-corrected visual acuity (BCVA), intraocular pressure, medication changes.

Main Results:

  • 95% of patients achieved significant CRT reduction within 16 weeks (P<.01).
  • 61% experienced improved BCVA at 8 weeks (P<.05).
  • 90% of patients on systemic corticosteroids reduced their dosage, with 90% reducing to <7.5 mg/day.

Conclusions:

  • DEX implants are effective in controlling refractory uveitis, improving CRT and BCVA.
  • Localized DEX therapy reduces the systemic corticosteroid burden in NIU patients.
  • Findings align with larger studies, supporting DEX implants as a valuable treatment option.