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The "All of Us" Research Program.

, Joshua C Denny1, Joni L Rutter1

  • 1From the Departments of Biomedical Informatics and Medicine, Vanderbilt University Medical Center, Nashville (J.C.D.); the National Center for Advancing Translational Sciences (J.L.R.) and the All of Us Research Program (G.J., E.D.), National Institutes of Health, Bethesda, MD; the Institute for Genomic Medicine and Department of Neurology, Columbia University Irving Medical Center, New York (D.B.G.); and the Broad Institute, Cambridge (A.P., J.W.S.), and the Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston (J.W.S.) - both in Massachusetts.

The New England Journal of Medicine
|August 15, 2019
PubMed
Summary
This summary is machine-generated.

The All of Us Research Program is building a diverse health dataset from over 1 million participants to accelerate precision medicine. This initiative aims to improve disease prevention and treatment by considering individual differences.

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Area of Science:

  • Biomedical Research
  • Precision Medicine
  • Public Health

Background:

  • Observational cohort studies are crucial for disease prevention and treatment.
  • Existing cohorts often lack diversity and comprehensive phenotype data.
  • The All of Us Research Program addresses these limitations.

Purpose of the Study:

  • To enroll at least 1 million diverse individuals in the United States.
  • To accelerate biomedical research and enhance disease prevention and treatment.
  • To develop new methods for data generation, access, and broad availability.

Main Methods:

  • Enrollment of participants aged 18+ from over 340 sites since May 2018.
  • Collection of health questionnaires, electronic health records (EHRs), physical measurements, and biospecimens.
  • Integration of digital health technology for comprehensive data capture.

Main Results:

  • Over 175,000 participants contributed biospecimens by July 2019.
  • More than 80% of biospecimen donors represent historically underrepresented groups.
  • EHR data collected from over 112,000 participants across 34 sites.

Conclusions:

  • The All of Us data repository will enable research considering individual differences in lifestyle, environment, and biology.
  • This resource will advance precision diagnosis, prevention, and treatment strategies.
  • The program promotes equitable participation in biomedical research.