Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of DNA Repair

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...

Overview of DNA Repair

Overview of DNA Repair

Base Excision Repair

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...

Base-pairing and DNA Repair

Base-pairing and DNA Repair

Mismatch Repair

Mismatch Repair

Nucleotide Excision Repair

Nucleotide Excision Repair

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rap1-mediated steric hindrance protects telomeres from MRX sensing.

Nature structural & molecular biology·2026

Same author

Sgs1 and Esc2 suppress chromosome translocations induced by a replication fork barrier in Saccharomyces cerevisiae.

DNA repair·2026

Same author

Asymmetrical recognition and processing of double-strand breaks formed during DNA replication.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Cohesin reconstitution and homologous recombination repair of DNA double-strand breaks in late mitosis.

eLife·2025

Same author

Asymmetrical recognition and processing of double-strand breaks formed during DNA replication.

bioRxiv : the preprint server for biology·2025

Same author

The Slx4-Rad1-Rad10 nuclease differentially regulates deletions and duplications induced by a replication fork barrier.

PLoS genetics·2025

Same journal

Sparganosis.

The New England journal of medicine·2026

Same journal

Caring for an Aging America - The Looming Crisis of the Long-Term-Care Workforce.

The New England journal of medicine·2026

Same journal

For Those Left Behind.

The New England journal of medicine·2026

Same journal

Colliding Forces - The Aging of the Baby Boom Generation and Contracting Nursing-Home Supply.

The New England journal of medicine·2026

Same journal

Mandated State-Level Surveillance of Assisted Reproductive Technology - An Emerging Threat in the United States.

The New England journal of medicine·2026

Same journal

Ebola at 50 - Lessons for Outbreak Response and Preparedness.

The New England journal of medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 20, 2026

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Published on: May 24, 2017

Recognition for Discoveries in DNA Repair

Hannah L Klein¹, Lorraine S Symington¹

¹From the New York University Medical Center, Department of Biochemistry and Molecular Pharmacology, New York, NY.

The New England Journal of Medicine

|August 15, 2019

Summary

No abstract available in PubMed .

More Related Videos

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling

Published on: October 8, 2019

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells

Published on: September 8, 2010

Related Experiment Videos

Last Updated: Jan 20, 2026

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Published on: May 24, 2017

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling

Published on: October 8, 2019

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells

Published on: September 8, 2010