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Age-related changes in human sperm DNA integrity.

Aleksandra Rosiak-Gill1,2, Kamil Gill1, Joanna Jakubik1

  • 1Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, Szczecin 71-210, Poland.

Aging
|August 15, 2019
PubMed
Summary

Advanced paternal age is linked to reduced semen volume and increased sperm DNA fragmentation, impacting male fertility potential. DNA integrity assessment is more clinically useful than standard semen analysis for older men.

Keywords:
TUNELmale fertilitypaternal agesperm DNA integritystandard semen characteristic

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Area of Science:

  • Reproductive Medicine
  • Andrology
  • Sperm Biology

Background:

  • Male aging is associated with potential declines in semen quality.
  • The specific impact of paternal age on sperm DNA integrity remains debated.

Purpose of the Study:

  • To investigate the effect of paternal age on conventional semen parameters.
  • To assess the influence of paternal age on sperm DNA integrity and damage.

Main Methods:

  • Analysis of ejaculated sperm cells from 1124 men aged 40 years and older, and younger than 40 years.
  • Evaluation of semen volume and sperm DNA fragmentation index (DFI).

Main Results:

  • Older men (≥40 years) exhibited decreased semen volume and a higher percentage of sperm DNA fragmentation (DFI) compared to younger men.
  • Increased incidence of high sperm DNA damage (>10% DFI) was observed in men aged ≥40 years.
  • Older men had more than double the odds of high sperm DNA damage.

Conclusions:

  • Advanced paternal age has a detrimental effect on sperm chromatin integrity.
  • Sperm DNA integrity evaluation offers greater clinical utility than standard semen analysis for assessing male fertility potential.