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Overweight Proxies Are Associated with Atopic Asthma: A Matched Case-Control Study
Manuela Gramss1,2, Tobias Lipek3,4,5, Mandy Vogel3,4
1Hospital for Children and Adolescents, Centre for Paediatric Research Leipzig, University Hospitals, Leipzig University, Leipzig, Germany, M.Gramsz@gmx.de.
Hormone Research in Paediatrics
|August 15, 2019
Summary
Overweight is linked to childhood asthma, particularly in children with atopy (allergic conditions). Waist-to-height ratio was a significant predictor, highlighting the need for age-matched studies.
Area of Science:
- Pediatric Allergy and Immunology
- Childhood Obesity Research
- Respiratory Health Studies
Background:
- The relationship between childhood overweight and asthma is complex, with inconsistent findings on measurement methods.
- Age-dependent changes in atopy, overweight, and asthma are often inadequately controlled in research.
Purpose of the Study:
- To compare associations between various overweight measures (waist circumference, waist-to-height ratio, neck circumference, BMI) and asthma occurrence.
- To rigorously control for age-related factors in assessing these associations.
Main Methods:
- Conditional logistic regression analysis was performed on 157 children with asthma and 471 matched controls (aged 6-17 years).
- Matching criteria included age and atopy status; additional influencing factors were investigated.
Main Results:
- All overweight indicators showed a positive association with asthma in children with atopy.
- Waist-to-height ratio (WHtR-SD score) was significantly associated with asthma (OR 1.26, p=0.025), even after adjusting for covariates.
- No significant difference in interleukin-6 or high-sensitivity C-reactive protein levels was observed between atopic and non-atopic groups.
Conclusions:
- In this cohort, overweight appears to increase asthma risk primarily when co-occurring with atopy.
- The study emphasizes the necessity of precise age-matching and longitudinal designs to elucidate causal relationships between overweight, atopy, and asthma.
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