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Updated: Jan 20, 2026

Dynamic Electrochemical Measurement of Chloride Ions
Published on: February 5, 2016
Discrepancy in Chloride Measurement with Decreasing Bicarbonate Concentrations
Background:
Accurate chloride measurement is important in critically ill patients.
Methods:
Chloride concentration measured simultaneously between the central laboratory (indirect ion-selective electrode) and blood gas analysis (direct ion-selective electrode) were compared.
Results:
We report a discrepancy with chloride measurement between the central laboratory and blood gas analysis at low bicarbonate levels.
Conclusions:
Caution should be applied while interpreting the chloride concentration when indirect ion-selective electrode methodology is used, especially in the setting of low serum bicarbonate levels.
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