Related Experiment Video

Updated: Jan 20, 2026

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
09:28

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

9.3K

Persistent Plus Disease Subsequent to Panretinal Photocoagulation in an Infant With Retinopathy of Prematurity

Saumya M Shah, Natalia F Callaway, Darius M Moshfeghi

    Ophthalmic Surgery, Lasers & Imaging Retina
    |August 16, 2019
    PubMed

    Insights

    Plus disease, a predictor of retinopathy of prematurity (ROP) progression, may persist in premature infants with comorbidities like anemia. This case highlights persistent plus-like disease after ROP treatment.

    Area of Science:

    • Ophthalmology
    • Neonatology
    • Medical Imaging

    Background:

    • Plus disease, characterized by vascular dilation and tortuosity, is a key indicator of retinopathy of prematurity (ROP) progression.
    • Resolution of plus disease signifies early ROP regression.
    • Comorbidities such as anemia and cardiovascular disease can lead to persistent plus-like disease even after successful ROP treatment.

    Purpose of the Study:

    • To present a case of persistent plus-like disease in a premature infant following ROP treatment.
    • To discuss the implications of comorbidities on ROP management.

    Main Methods:

    • Case report of a 24-week premature infant.
    • Treatment with panretinal photocoagulation for stage 3, zone II ROP.

    Main Results:

    • The infant presented with persistent plus-like disease despite successful ROP treatment.
    • This suggests underlying comorbid conditions may influence disease presentation and resolution.

    Conclusions:

    • Persistent plus-like disease in ROP patients warrants consideration of comorbid conditions.
    • Further investigation into the relationship between comorbidities and ROP progression/regression is needed.

    More Related Videos

    Application of Optical Coherence Tomography to a Mouse Model of Retinopathy08:22

    Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

    Published on: January 12, 2022

    5.2K
    Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy07:45

    Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

    Published on: December 30, 2025

    286

    Related Concept Videos

    Drug Dosing: Infants and Children01:29

    Drug Dosing: Infants and Children

    Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
    262
    Inflammatory Bowel Disease II: Crohn's Disease01:30

    Inflammatory Bowel Disease II: Crohn's Disease

    Introduction
    Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
    Crohn's disease
    Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
    975
    Immunodeficiency Diseases01:25

    Immunodeficiency Diseases

    Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
    There are three main causes of immunodeficiency...
    2.0K
    Principles of Disease Surveillance01:26

    Principles of Disease Surveillance

    Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
    477
    Parkinson's Disease: Treatment01:24

    Parkinson's Disease: Treatment

    Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
    Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
    1.0K
    Alzheimer's Disease: Treatment01:22

    Alzheimer's Disease: Treatment

    Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
    832