Taro-corms mucilage-alginate microspheres for the sustained release of pregabalin: In vitro &in vivo evaluation
Related Experiment Video
Updated: Jan 20, 2026

Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres
Published on: June 7, 2024
Shazia Akram Ghumman1, Sajid Bashir1, Sobia Noreen2
1College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
Abstract:
Taro corms mucilage (TCM)-alginate microspheres had been prepared using TCM and alginate as blend and coated form in various ratios through inotropic gelation approach. The prepared microspheres have been of sphere-formed having coarse surface with average particle size within the range 498 μm ± 0.17 to 715 μm ± 0.34. The drug entrapment efficiency was 74.33 ± 0.04% to 89.63 ± 0.01% and swelling of microspheres followed the pattern (blended >coated >plain). FTIR research showed that there had been no interactions among pregabalin and polymers used; these microspheres were further characterized by DSC and XRD. The in vitro drug release followed sustained release (Korsmeyer-Peppas model) pattern (R2 = 0.9552-0.9906) and value of n > 1 showed that drug released by means of anomalous (non-Fickian) diffusion. The in vivo research established that there were highly significant difference with p < 0.001 within the pharmacokinetic parameters (Cmax, t½, AUC0-∞, Ke), while pregabalin microspheres in comparison to pure drug. Therefore, it is concluded that blended microspheres has greater bioavailability for pregabalin with sustained release effect. This evolved that TCM has been proved to be emerging potential pharmaceutical excipient for sustained release drug delivery systems.
Related Concept Videos
Sustainable Development
In Vitro Drug Release Testing: Overview, Development and Validation
Design Example: Sustainability in Concrete Building
There are multiple approaches to achieve sustainability in a commercial concrete building. For instance, construct a concrete parking area under the building, utilizing pervious concrete paver blocks in open areas to facilitate rainwater collection through an underground...
Equivalence: In Vitro and In Vivo Bioequivalence
Energy-releasing Steps of Glycolysis
The first energy-releasing step—the 6th step of glycolysis...
Drug Product Performance: In Vitro–In Vivo Correlation

