Related Experiment Video
Updated: Jan 20, 2026
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
[Risk factors for recurrence within 2 years in children with medulloblastoma]
Jing-Jing Liu1, Yan-Ling Sun, Shu-Xu DU
1Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China. lwxi@sina.com.
Objective:
To investigate the risk factors for recurrence of medulloblastoma (MB) within 2 years and their influence on progression-free survival (PFS).
Methods:
A retrospective analysis was performed for the clinical data of 123 children with MB who were admitted from January to December, 2017. According to the presence or absence of recurrence, they were divided into recurrence group with 30 children and non-recurrence group with 93 children. The risk factors for recurrence within 2 years were analyzed, and PFS was compared between the children with different risk factors.
Results:
Large-cell/anaplastic type and M stage were risk factors for MB recurrence within 2 years. The risk of recurrence in the children with M+ MB was 3.525 times that in those with M0 MB, and the risk of recurrence in the children with large-cell/anaplastic MB was 3.358 times that in those with classic MB (P<0.05). The survival analysis showed that the median PFS time was 20 months in the children with M+ MB, and the 20-month PFS rate was 50% ± 11% in the children with M+ MB and 81% ± 5% in those with M0 MB (P<0.05). The 20-month PFS rate was 80% ± 5% in the children with classic MB, 65% ± 10% in those with desmoplastic/nodular MB, 86% ± 13% in those with MB with extensible nodularity, and 36% ± 20% in those with large-cell/anaplastic MB (P<0.05).
Conclusions:
Recurrence is an important influencing factor for the prognosis of MB, and M+ stage and large-cell/anaplastic MB are risk factors for recurrence. Children with such risk factors tend to have a low PFS rate.
Insights
Medulloblastoma (MB) recurrence is linked to poor prognosis. Identifying M+ stage and large-cell/anaplastic MB as key risk factors can improve patient outcomes and progression-free survival (PFS).
Area of Science:
- Pediatric Oncology
- Neuro-oncology
- Cancer Research
Background:
- Medulloblastoma (MB) is a common malignant brain tumor in children.
- Recurrence significantly impacts patient prognosis and survival.
- Identifying early risk factors for MB recurrence is crucial for timely intervention.
Purpose of the Study:
- To identify risk factors for medulloblastoma (MB) recurrence within two years.
- To evaluate the influence of these risk factors on progression-free survival (PFS).
Main Methods:
- Retrospective analysis of clinical data from 123 pediatric MB patients.
- Patients were categorized into recurrence (30) and non-recurrence (93) groups.
- Statistical analysis was used to determine risk factors and compare PFS.
Main Results:
- Large-cell/anaplastic MB type and M+ stage were significant risk factors for recurrence.
- Patients with M+ MB had 3.5 times higher recurrence risk than M0 MB.
- Patients with large-cell/anaplastic MB had 3.3 times higher recurrence risk than classic MB.
- Median PFS was 20 months for M+ MB patients, with a 20-month PFS rate of 50% vs. 81% for M0 MB.
- The 20-month PFS rate for large-cell/anaplastic MB was 36%, significantly lower than other subtypes.
Conclusions:
- Recurrence is a critical factor affecting medulloblastoma prognosis.
- M+ stage and large-cell/anaplastic histology are significant risk factors for MB recurrence.
- Children with these risk factors exhibit a lower progression-free survival rate, necessitating closer monitoring and tailored treatment strategies.
More Related Videos
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:12Relative Risk
04:01Factors Affecting Solubility
02:16Transcription Factors
03:08Electrolytes: van't Hoff Factor
The colligative properties of a solution depend only on the number, not on the identity, of solute species dissolved. The concentration terms in the equations for various colligative properties (freezing point depression, boiling point elevation, osmotic pressure) pertain to all solute species present in the solution. Nonelectrolytes dissolve physically without dissociation or any other accompanying process. Each molecule that dissolves yields one...
02:35Transcription Elongation Factors
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...