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Related Experiment Videos

'Obesageing': Linking obesity & ageing.

Shampa Ghosh1, Jitendra Kumar Sinha2, Manchala Raghunath1

  • 1Endocrinology and Metabolism Division, ICMR-National Institute of Nutrition, Hyderabad, India.

The Indian Journal of Medical Research
|August 17, 2019
PubMed
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Obesity and ageing share common health risks and physiological declines, a phenomenon termed "Obesageing." A novel rodent model (WNIN/Ob) aids in studying these shared mechanisms for future health strategies.

Area of Science:

  • Gerontology
  • Obesity research
  • Public health

Background:

  • Obesity is a leading cause of preventable mortality globally.
  • The increasing geriatric population presents a significant public health challenge.
  • Both obesity and ageing are linked to cardiovascular diseases, diabetes, and dementia.

Purpose of the Study:

  • To review the commonalities between obesity and ageing, termed 'Obesageing'.
  • To introduce a novel rodent model (WNIN/Ob) for studying obesageing.
  • To facilitate understanding of shared mechanisms and develop future health strategies.

Main Methods:

  • Literature review of obesity and ageing commonalities.
  • Description of the WNIN/Ob rodent model.
  • Analysis of shared pathological and physiological pathways.
Keywords:
Accelerated ageingWistar of National Institute of Nutrition obese ratcognitive declinedementiainflammation - nicotinamide adenine dinucleotideoxidative stress

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Main Results:

  • Identified significant overlaps in health risks and physiological declines between obesity and ageing.
  • Characterized the WNIN/Ob model exhibiting morbid obesity and premature ageing.
  • Highlighted the potential of the WNIN/Ob model for mechanistic studies.

Conclusions:

  • Obesageing represents a critical intersection of two major global health challenges.
  • The WNIN/Ob model offers a valuable tool for investigating the complex interplay of obesity and ageing.
  • Further research using this model can inform interventions for age-related diseases and obesity.