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Pediatric codeine prescriptions in outpatient and inpatient settings in Korea

Dajeong Kim, Inmyung Song, Dongwon Yoon

  • 1School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, South Korea.

The American Journal of Managed Care
|August 17, 2019
PubMed

Insights

Codeine prescriptions are common for children under 12 in Korea, particularly for outpatients. Limiting pediatric codeine use is crucial to prevent adverse events.

Area of Science:

  • Pediatric pharmacology
  • Public health
  • Drug utilization studies

Background:

  • Codeine is a commonly prescribed opioid analgesic.
  • Pediatric codeine use requires careful consideration due to potential risks.
  • Understanding prescription patterns is essential for safe medication practices.

Purpose of the Study:

  • To determine the frequency of codeine prescriptions for children under 12 years old in Korea.
  • To identify patient and healthcare system characteristics associated with pediatric codeine use.

Main Methods:

  • Retrospective observational study using the Korea Health Insurance Review and Assessment Service National Patient Sample database (2011-2016).
  • Analysis of pediatric codeine users (<12 years) by demographics, medical setting, and diagnoses.
  • Logistic regression to identify factors associated with codeine prescription.

Main Results:

  • Codeine was prescribed to 55.8% of pediatric outpatients and 1.7% of inpatients.
  • Higher odds of codeine prescription were observed in outpatient clinics and public hospitals.
  • Inpatient prescriptions at public hospitals showed the highest adjusted odds ratio for codeine use.

Conclusions:

  • Codeine is frequently prescribed to pediatric outpatients in Korea, especially in primary care settings.
  • There is a need to implement strategies to reduce unnecessary codeine prescriptions in children.
  • Limiting pediatric codeine use is necessary to mitigate the risk of codeine-related adverse events.
Abstract

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