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Image Rendering Techniques in Postmortem Computed Tomography: Evaluation of Biological Health and Profile in Stranded Cetaceans
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Distributed Biological Foundries for Global Health.

Jose Gomez-Marquez1, Kimberly Hamad-Schifferli2

  • 1Little Devices Lab, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, 02139, USA.

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Biological manufacturing is shifting towards distributed biological foundries, enabling broader access to tools for creating novel therapeutics, diagnostics, and reagents. This trend is crucial for advancing biomedical applications.

Keywords:
biofabricationbiological foundrybioprocessingdemocratized life sciencesdistributed manufacturing

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Area of Science:

  • Biotechnology
  • Industrial Biology
  • Bioprocessing

Background:

  • Historically, manufacturing has decentralized, a trend now emerging in biological manufacturing.
  • Biological foundries are rising, enabling synthesis, growth, isolation, and purification of biologics.
  • This shift has significant implications for healthcare, diagnostics, and therapies.

Purpose of the Study:

  • To discuss factors driving the growth of distributed biological manufacturing.
  • To identify existing examples of biological foundries.
  • To argue for the inevitability and importance of adapting to this trend.

Main Methods:

  • Review of historical manufacturing trends.
  • Analysis of enabling factors for biological foundries (e.g., biological parts, low-cost hardware).
  • Categorization of existing biological foundries based on accessibility.

Main Results:

  • Distributed biological manufacturing is facilitated by accessible biological components and programmable hardware.
  • Biological foundries range from elite-access to broadly accessible models.
  • The trend towards distributed biological manufacturing is identified as inevitable.

Conclusions:

  • Adapting to distributed biological manufacturing is essential for advancing new therapeutics, sensors, diagnostics, and reagents.
  • The rise of accessible biological foundries democratizes biomanufacturing.
  • This trend promises to accelerate innovation in biomedical applications.