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Natural product-based nanoformulations for cancer therapy: Opportunities and challenges

Dharambir Kashyap1, Hardeep Singh Tuli2, Mukerrem Betul Yerer3

  • 1Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, Punjab, India.

Seminars in Cancer Biology
|August 18, 2019
PubMed

Insights

Natural product-based nanoformulations offer a promising approach to cancer treatment, overcoming limitations of conventional therapies. These nanotherapeutics enhance drug delivery, improve efficacy, and reduce side effects for better patient outcomes.

Area of Science:

  • Oncology
  • Nanotechnology
  • Pharmacology

Background:

  • Conventional cancer therapies (surgery, chemotherapy, immunotherapy, radiotherapy) have significant limitations including toxicity, side effects, and drug resistance.
  • Natural product-based nanoformulations represent an emerging field for disease treatment, particularly cancer.
  • Nanotechnology offers novel therapeutic strategies that address limitations of conventional drug delivery systems.

Purpose of the Study:

  • To explore the application and benefits of natural product-based nanoformulations in cancer therapy.
  • To highlight how nanotherapeutics can overcome drawbacks of traditional cancer treatments.
  • To investigate the potential of integrating phytotherapy with nanotechnology for improved clinical outcomes.

Main Methods:

  • Review and analysis of existing research on natural product-based nanoformulations in various model systems.
  • Comparison of nanotherapeutic approaches with conventional cancer treatment modalities.
  • Focus on the targeted delivery capabilities of nanoparticles.

Main Results:

  • Natural product-based nanoformulations demonstrate improved specificity and reduced side effects compared to conventional methods.
  • Nanoparticles can effectively target tumor cells, enhancing therapeutic efficacy.
  • Nanotherapeutics show promise in overcoming issues like low aqueous solubility, poor bioavailability, and multidrug resistance.

Conclusions:

  • The integration of phytotherapy and nanotechnology presents a significant advancement in cancer therapeutics.
  • Natural product-based nanoformulations have the potential to improve patient response, survival rates, and overall clinical outcomes.
  • This approach offers a more targeted and less toxic alternative for cancer treatment.
Keywords:
AnticancerCancerNanoformulationNatural productSynergistic effectTherapeutic

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