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Related Experiment Video

Updated: Jan 20, 2026

siRNA Screening to Identify Ubiquitin and Ubiquitin-like System Regulators of Biological Pathways in Cultured Mammalian Cells

siRNA Screening to Identify Ubiquitin and Ubiquitin-like System Regulators of Biological Pathways in Cultured Mammalian Cells

Published on: May 24, 2014

Enkephalinase regulation.

Manuel Ramírez-Sánchez¹, Isabel Prieto¹, Ana-Belén Segarra¹

¹Department of Health Sciences, University of Jaén, Jaén, Spain.

Vitamins and Hormones

|August 19, 2019

Summary

This summary is machine-generated.

Endogenous opioids, like enkephalins, are regulated by enzymes called enkephalinases. Understanding factors influencing these enzymes is key for developing targeted pain therapies.

Keywords:

Daily rhythm Developmental changes Dietary factors Enkephalinases Gender differences Neurotransmitters interactions Steroids influence Stress

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Area of Science:

Neuroscience
Biochemistry
Pharmacology

Background:

Opium's effects have been known for millennia, but endogenous opioids (e.g., enkephalins) were discovered recently.
Enkephalins are endogenous substances with opioid-like properties.

Purpose of the Study:

To describe the regulatory mechanisms of enkephalin function, focusing on proteolytic enzymes (enkephalinases).
To highlight the importance of understanding regulatory factors for therapeutic strategies.

Main Methods:

Discussion of regulatory factors affecting enkephalinase activity.
Review of regional and subcellular distribution, developmental and diurnal variations.
Exploration of hormonal influences, stress, dietary factors, and neurotransmitter interactions.

Main Results:

Enkephalinase activity is regulated by multiple endogenous and exogenous factors.
These factors influence the control of enkephalin action.
Knowledge of these factors is crucial for therapeutic intervention.

Conclusions:

Developing specific enkephalinase inhibitors requires a deep understanding of regulatory influences.
This knowledge can inform adapted therapeutic strategies for pain and other conditions involving enkephalins.