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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Changes in corneal endothelial cell density in patients with primary open-angle glaucoma
1Department of Ophthalmology, 4 Affiliated Hospital of China Medical University, Eye hospital of China Medical University, Key Laboratory of Lens Research of Liaoning Province, Shenyang 110005, Liaoning Province, China.
World Journal of Clinical Cases
|August 20, 2019
Summary
Primary open-angle glaucoma (POAG) is associated with reduced corneal endothelial cell density. This may result from elevated intraocular pressure and glaucoma medication toxicity.
Area of Science:
- Ophthalmology
- Corneal Science
- Glaucoma Research
Background:
- Glaucoma is linked to corneal endothelium loss, potentially due to elevated intraocular pressure (IOP), medication toxicity, or surgical interventions.
- Corneal endothelium changes are increasingly recognized in glaucoma patients.
Purpose of the Study:
- To investigate corneal endothelial cell density in Chinese patients with primary open-angle glaucoma (POAG).
- To compare corneal endothelium changes in POAG patients versus age-matched healthy controls.
- To analyze correlations between corneal endothelial parameters and mean IOP in POAG.
Main Methods:
- A case control study involving 60 eyes of 60 POAG patients and healthy controls.
- Exclusion criteria ensured a homogenous study population, free from confounding ocular or systemic conditions.
- Indirect specular microscopy assessed central corneal endothelial cell density, area, and cell counts; IOP was measured via Goldmann tonometry.
Main Results:
- POAG patients exhibited significantly lower endothelial cell density (2757 ± 262 cells/mm²) compared to healthy controls (2959 ± 236 cells/mm²).
- Endothelial cell density was lower in POAG patients using medication compared to untreated POAG patients.
- A negative correlation was found between endothelial cell density and mean IOP; cell area showed a positive correlation with mean IOP.
Conclusions:
- Primary open-angle glaucoma is associated with reduced corneal endothelial cell density compared to healthy individuals.
- Elevated IOP and glaucoma medication toxicity are potential contributing factors to corneal endothelial cell loss in POAG.
- Corneal endothelium status should be considered in the management of POAG.
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