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The effects of curcumin supplementation on endothelial function: A systematic review and meta-analysis of randomized

Jamal Hallajzadeh1, Alireza Milajerdi2,3, Fariba Kolahdooz4

  • 1Department of Biochemistry and Nutrition, Maraghe University of Medical Science, Maraghe, Iran.

Phytotherapy Research : PTR
|August 20, 2019
PubMed

Insights

Curcumin supplementation significantly improves flow-mediated dilation (FMD), a key indicator of endothelial function. However, it did not show significant effects on other cardiovascular disease risk markers like pulse wave velocity (PWV).

Area of Science:

  • Cardiovascular Medicine
  • Nutritional Science
  • Pharmacology

Background:

  • Endothelial dysfunction is a significant risk factor for cardiovascular disease (CVD).
  • Curcumin, a compound found in turmeric, is being investigated for its potential cardiovascular benefits.
  • Supplementation strategies are crucial for managing CVD risk factors.

Purpose of the Study:

  • To systematically evaluate the impact of curcumin supplementation on endothelial function markers.
  • To synthesize evidence from randomized controlled trials (RCTs) on curcumin's effects on CVD risk.
  • To assess curcumin's influence on flow-mediated dilation (FMD), pulse wave velocity (PWV), and other endothelial markers.

Main Methods:

  • A systematic literature search was conducted across major databases (PubMed, EMBASE, Scopus, Web of Science, Cochrane Library).
  • Ten RCTs with 11 effect sizes were included in the meta-analysis.
  • Cochrane Collaboration's risk of bias tool assessed study quality; random-effects models were used for data synthesis.

Main Results:

  • Curcumin supplementation significantly increased flow-mediated dilation (FMD) (WMD: 1.49; 95% CI [0.16, 2.82]).
  • No significant effects were observed on pulse wave velocity (PWV), augmentation index (Aix), endothelin-1 (ET-1), or soluble intercellular adhesion molecule-1 (sICAM-1).
  • Heterogeneity was assessed using Cochran's Q test and I-square statistic.

Conclusions:

  • Curcumin supplementation demonstrates a beneficial effect on improving endothelial function, specifically FMD.
  • Curcumin did not significantly alter other key markers of vascular health, including PWV, Aix, ET-1, and sICAM-1.
  • Further research may explore optimal dosing and specific populations for curcumin's cardiovascular benefits.

Keywords:
cardiovascular diseasecurcuminendothelial functionmeta-analysis

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