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Chronic Systemic Symptoms in Head and Neck Cancer Patients

Barbara A Murphy1, Elizabeth Wulff-Burchfield1, Michael Ghiam2

  • 1Department of Medicine and Division of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN.

Journal of the National Cancer Institute. Monographs
|August 20, 2019
PubMed

Insights

This study explores inflammation

Area of Science:

  • Oncology
  • Immunology
  • Symptom Science

Background:

  • Systemic symptoms, often occurring in clusters, have historically been studied in isolation, creating knowledge gaps.
  • Recent research on systemic symptoms has primarily focused on nonmalignant diseases, with limited translation to oncology.
  • Understanding the systemic effects of disease and treatment is crucial for comprehensive patient care.

Purpose of the Study:

  • To explore inflammation as a key contributor to systemic symptoms and sickness behavior.
  • To discuss common systemic symptom manifestations in cancer survivors.
  • To review specific data on systemic symptoms in head and neck cancer survivors.

Main Methods:

  • Literature review focusing on inflammation, systemic symptoms, and sickness behavior.
  • Analysis of research on systemic symptom clusters in various chronic diseases.
  • Synthesis of findings relevant to cancer survivors, particularly those with head and neck cancer.

Main Results:

  • Inflammation is a significant factor underlying systemic symptoms and sickness behavior.
  • Common systemic manifestations in cancer survivors include fatigue, pain, and cognitive changes.
  • Evidence suggests a strong link between inflammation and these symptoms in head and neck cancer survivors.

Conclusions:

  • Addressing inflammation is critical for managing systemic symptoms in cancer patients.
  • A holistic approach is needed to bridge knowledge silos and understand systemic symptom clusters.
  • Further research is required to fully elucidate the role of inflammation in cancer-related systemic symptoms.

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