Brain structures associated with eating behaviors in normal-weight young females

Eating behaviors play an important role in individuals' development, and restrained eaters have a higher risk of obesity in the future. In the present study, we used the Three-Factor Eating Questionnaire to measure restrained eating, uncontrolled eating, and emotional eating in 158 young, normal-weight, Chinese women. We developed a multiple linear regression model to identify significant structural brain changes associated with the above-mentioned eating behaviors. Uncontrolled eating scores were positively associated with the gray matter volume (GMV) of the cerebellum, and negatively associated with the GMV on the left side of the anterior cingulate cortex, middle cingulate cortex, and supplementary motor areas, indicating that uncontrolled eating behaviors not only are less inhibitory but also appear to be associated with the low-level processing of appetite. Increased GMV on the right side of the precuneus was associated with a higher level of restrained eating, which might be thus related to a lower sensitivity to behavioral inhibition in young females who follow a diet. In addition, we did not find a relationship between emotional eating behavior and GMV. Our findings show that eating-behavior-related structural brain changes may lead to a decrease in inhibition and an increase in food sensitivity.