Endocrine Consequences of Childhood Cancer Therapy and Transition Considerations

Childhood cancer survivors are at risk for chronic health conditions related to their cancer or their therapy. Of these chronic sequelae, endocrinopathies are some of the most common complications and may include thyroid disorders, reproductive and pituitary dysfunction, and metabolic syndrome. It is important for the primary care physician and endocrinologist to be aware of these possible consequences, as many of them develop months or years after the initial cancer diagnosis and therapy. They may affect adolescents and young adults during a vulnerable time, when they are ideally transitioning into a more independent role in their care and possibly preparing to transfer their health care to new providers. The purpose of this article is to summarize the endocrine complications that may occur following therapy for childhood cancer, and to briefly describe specific considerations in transitioning this population. [Pediatr Ann. 2019;48(8):e326-e332.].