Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Graves' disease, multinodular goiter and subclinical hyperthyroidism.

Pierre Bel Lassen1, Aglaia Kyrilli2, Maria Lytrivi2

  • 1Department of endocrinology, université Libre de Bruxelles, Erasme University Hospital, route de Lennik 808, 1070 Brussels, Belgium; UMRS 1166 (Inserm), 91, boulevard de l'Hôpital, 75013 Paris, France.

Annales D'Endocrinologie
|August 21, 2019
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk of bone overstimulation in long-term PTH(1-34) therapy for hypoparathyroidism.

European journal of endocrinology·2026
Same author

Mapping transition of care for rare endocrine conditions: findings from a cross-sectional survey by the Endo-ERN ToC Working Group.

Endocrine connections·2026
Same author

SEMASEARCH Study Design: Real-World Evaluation of Semaglutide 2.4 mg in Adults With Severe Obesity Underrepresented in Clinical Trials.

Diabetes, obesity & metabolism·2026
Same author

A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases.

Nature communications·2026
Same author

Real-world performance of an AI system for diabetic retinopathy screening.

Scientific reports·2026
Same author

A new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data.

EMBO molecular medicine·2026

Subclinical hyperthyroidism, a condition with low thyroid-stimulating hormone (TSH), is linked to health risks like atrial fibrillation and osteoporosis. Treatment decisions should consider TSH levels and individual risk factors due to limited evidence.

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Clinical Research

Background:

  • Subclinical hyperthyroidism is defined by suppressed serum TSH with normal free T4 and T3 levels in asymptomatic individuals.
  • Its clinical management, particularly the decision to treat, remains a subject of ongoing debate within the medical community.

Purpose of the Study:

  • To review the current evidence regarding the association of subclinical hyperthyroidism with adverse health outcomes.
  • To provide guidance on managing subclinical hyperthyroidism in the absence of definitive randomized controlled trial data.

Main Methods:

  • Review of cross-sectional and longitudinal population-based studies.
  • Analysis of associations between subclinical hyperthyroidism and risks of atrial fibrillation, osteoporosis, cardiovascular mortality, and all-cause mortality.
Keywords:
Goitre multinodulaireHyperthyroïdie infra-cliniqueMultinodular goiterSubclinical hyperthyroidismTSHThyroidThyroïde

Related Experiment Videos

  • Evaluation of the lack of randomized clinical trials on treatment efficacy.

    • Main Results:

    • Observational studies indicate a correlation between subclinical hyperthyroidism and increased risks of atrial fibrillation, osteoporosis, and mortality.
    • No randomized clinical trials currently exist to confirm improved long-term health outcomes with treatment.

    Conclusions:

    • Treatment decisions for subclinical hyperthyroidism should be individualized.
    • Decision-making should incorporate TSH concentration and patient-specific risk factors, including age, menopausal status, osteoporosis, and cardiac disease.