Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

4.3K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.3K
Aging01:26

Aging

624
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
624
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.4K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.4K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.4K
Liver Histology01:27

Liver Histology

4.1K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
4.1K
Liver Physiology01:30

Liver Physiology

3.5K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Second-Line Practices in the Era of Immunotherapy in HCC: The CHIEF Cohort.

JHEP reports : innovation in hepatology·2026
Same author

Clinical predictors of response to Atezolizumab-bevacizumab in Child-Pugh B patients with hepatocellular carcinoma.

JHEP reports : innovation in hepatology·2026
Same author

ASO Visual Abstract: AFP Model Predicts Outcomes after Liver Resection: a Multicenter Retrospective Cohort Study.

Annals of surgical oncology·2026
Same author

AFP Model Predicts Outcomes After Liver Resection: A Multicenter Retrospective Cohort Study.

Annals of surgical oncology·2026
Same author

[Homeostasis or allostasis?]

Medecine sciences : M/S·2026
Same author

Second-line TKI after first-line immunotherapy-based treatment in advanced HCC: Reconstructed IPD meta-analysis.

JHEP reports : innovation in hepatology·2026

Related Experiment Video

Updated: Jan 20, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

34.9K

The aged liver: Beyond cellular senescence.

Manon Allaire1, Hélène Gilgenkrantz1

  • 1Université de Paris, Centre de recherche sur l'inflammation, Inserm-UMR1149, 75018 Paris, France.

Clinics and Research in Hepatology and Gastroenterology
|August 21, 2019
PubMed
Summary

As populations age, understanding the aged liver is crucial for managing chronic liver diseases and improving liver transplantation outcomes. This review details age-related liver changes and their clinical impact.

Keywords:
AgeingAutophagyInflammationMetabolismRegenerationTransplantation

More Related Videos

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

18.0K
Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
09:32

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

Published on: October 17, 2025

440

Related Experiment Videos

Last Updated: Jan 20, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

34.9K
Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

18.0K
Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
09:32

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

Published on: October 17, 2025

440

Area of Science:

  • Gerontology
  • Hepatology
  • Cellular Biology

Background:

  • The global population is aging, leading to a higher prevalence of chronic liver diseases in the elderly.
  • There is a growing need to expand the donor pool for liver transplantation, necessitating an understanding of aged livers.
  • Cellular senescence plays a significant role in age-related tissue modifications.

Purpose of the Study:

  • To review the morphological and functional changes in the aged liver.
  • To explore the impact of aging on liver metabolism, immune response, and regeneration.
  • To discuss the clinical implications of liver aging for disease and transplantation.

Main Methods:

  • Literature review focusing on cellular senescence and liver aging.
  • Analysis of age-induced modifications in liver structure and function.
  • Examination of signaling pathways involved in liver aging.
  • Discussion of clinical consequences and transplantation considerations.

Main Results:

  • Aging induces significant morphological and functional alterations in the liver.
  • Key changes affect liver metabolism, immune surveillance, and regenerative capacity.
  • Specific signaling pathways are implicated in mediating these age-related modifications.

Conclusions:

  • Understanding the aged liver is essential for addressing age-related chronic liver diseases.
  • Age-related liver changes have profound implications for both patients and organ donors in liver transplantation.
  • Further research into the mechanisms of liver aging can inform therapeutic strategies.