A novel micro drill design based on Ros-Drill^Ⓒ

Area of Science:

• Biomedical Engineering
• Microtechnology
• Cell Biology

Background:

• Current microinjection techniques often utilize mercury, posing toxicity risks to operators and cells.
• The need for safer, mercury-free alternatives in micro-manipulation is critical for biological research and medical procedures.

Purpose of the Study:

• To develop and present a novel, mercury-free micro drill device for precise manipulation of single living organisms.
• To offer a safer alternative to existing microinjection methods, improving success rates and usability.

Main Methods:

• Development of a micro drill device driven by a brushless motor, incorporating a micropipette holder.
• Utilizing a rotational piercing approach, similar to the Ros-Drill principle, with adjustable oscillation amplitude and frequency.
• Testing the device's efficacy in microinjection and biopsy procedures on various organisms.

Main Results:

• The novel micro drill demonstrated suitability for microinjection and biopsy tasks across different organisms.
• Achieved high success rates, ease of use, and a compact design.
• Confirmed compatibility with diverse manipulation systems, highlighting its versatility.

Conclusions:

• The developed mercury-free micro drill offers a safe and effective solution for micro-manipulation in biological research.
• The device's performance, usability, and adaptability make it a valuable tool for advancing techniques like microinjection and biopsy.