Related Experiment Video
Updated: Jan 20, 2026
11:39
Analyzing In Vivo Cell Migration using Cell Transplantations and Time-lapse Imaging in Zebrafish Embryos
Published on: April 29, 2016
8.2K
Dynamics phenotyping across length and time scales in collective cell migration
Rachel M Lee1, Wolfgang Losert2
1University of Maryland School of Medicine, Baltimore, MD, 21201, USA; Institute for Physical Science and Technology, University of Maryland, College Park, MD, 20742, USA.
Seminars in Cell & Developmental Biology
|August 21, 2019
Summary
Collective cell migration across multiple scales reveals insights into epithelial cell sheet dynamics. Particle image velocimetry quantifies motion, linking cell-scale behaviors to jamming transitions and active motility.
Area of Science:
- Cell biology
- Biophysics
- Quantitative biology
Background:
- Collective cell migration is crucial for development and disease.
- Understanding migration across scales (microns to millimeters) is challenging.
- Epithelial cell sheets offer a model system for studying collective motion.
Purpose of the Study:
- To review methods for measuring collective cell migration phenotypes.
- To analyze migration across diverse length and time scales.
- To compare collective cell migration to jamming transitions.
Main Methods:
- Focus on epithelial cell sheets and migration metrics.
- Utilize particle image velocimetry (PIV) for image analysis.
- Compare cell motion to fluid dynamics and jamming phenomena.
Main Results:
- PIV yields quantitative metrics for migration across scales.
- Collective cell migration exhibits characteristics of jammed matter.
- Active motility and cell-cell guidance influence collective behavior.
Conclusions:
- Multi-scale migration metrics link cell-scale signals to collective behavior.
- Understanding jamming and active processes is key to collective cell migration.
- Quantitative phenotypes aid in developing predictive migration models.
More Related Videos
Related Concept Videos
01:19Cell Migration
6.4K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.4K
01:09Cell Migration
18.7K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.7K
02:41pH Scale
79.0K
Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
79.0K
01:35Cancer Cell Migration through Invadopodia
3.2K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.2K
01:21Chemotaxis and Direction of Cell Migration
4.4K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
4.4K
01:18Role of Myosin in Cell Migration
3.2K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
3.2K