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Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
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Diffusion01:12

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Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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Statistical and spatial correlation between diffusion and perfusion MR imaging parameters: A study on soft tissue

Georgios S Ioannidis1, Katerina Nikiforaki2, Apostolos Karantanas3

  • 1Foundation for Research and Technology - Hellas (FORTH), Institute of Computer Science (ICS), Computational Bio-Medicine Laboratory (CBML), Heraklion, Greece; Medical School, University of Crete, Heraklion, Greece. Electronic address: http://www.ics.forth.gr/cbml/.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|August 21, 2019
PubMed
Summary
This summary is machine-generated.

Diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) MRI revealed a correlation between micro-perfusion fraction (f-IVIM) and plasma volume (vp-GCTT) in soft tissue sarcomas. These MRI techniques offer valuable insights for guiding treatment planning.

Keywords:
Diffusion Weighted ImagingDynamic contrast enhanced MR imagingIntravoxel incoherent motionMusculoskeletal tumorsSoft tissue sarcoma

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Area of Science:

  • Radiology and Imaging Science
  • Oncology
  • Biomedical Engineering

Background:

  • Malignant soft tissue tumors require accurate characterization for effective treatment.
  • Quantitative MRI parameters from diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) MRI offer potential biomarkers for tumor assessment.
  • Understanding the correlation and spatial agreement between these parameters is crucial for improving diagnostic accuracy.

Purpose of the Study:

  • To investigate the correlation between quantitative diffusion and perfusion MR parameters in patients with malignant soft tissue tumors.
  • To assess the spatial agreement of malignancy hallmarks indicated by diffusion and perfusion biomarkers.

Main Methods:

  • 25 patients with soft tissue sarcoma underwent 1.5T MRI.
  • Voxel-based parametric maps were generated using Intra-Voxel Incoherent Motion (IVIM), Extended Toft's (ETM), and Gamma Capillary Transit time (GCTT) models.
  • Nonlinear least squares and root mean squared error (RMSE) were employed for parameter quantification and DCE fitting accuracy assessment.

Main Results:

  • A significant positive correlation (r > 0.5) was observed between micro-perfusion fraction (f-IVIM) and plasma volume (vp-GCTT).
  • No significant correlation was found between other diffusion and DCE-derived parameters.
  • The overlap between regions indicating high cellularity (DWI) and high vascular permeability (DCE) ranged from 6% to 30%.

Conclusions:

  • A linear relationship exists between f-IVIM and vp-GCTT in soft tissue sarcomas.
  • Combined DWI and DCE MRI provide valuable information on aggressive tumor characteristics.
  • These findings can aid in guiding pre-operative biopsy and optimizing overall treatment planning for soft tissue sarcomas.