[Effect of the nonhormonal bisanionic aromatic compound IEM 967 on the pituitary-ovarian system of rats]

A new original drug IEM-967 (a sulfoderivative in aromatic series with riged molecular structure) exhibited both stimulating and inhibitory gonadotropic effects, depending on reactivity of the system hypothalamus-hypophysis-gonads as well as on periods of the drug administration, in chronic experiments on rats. At the same time, the drug did not possess any peripheral estrogenic action on uterus and vaginal epithelium. The drug both resembled and had a number of differences and advantages as compared with the earlier synthesized compound sigetin in its effect on the gonadotropics function of hypophysis. Synthesis and study of effective medicinal agents causing selective effects on the gonadotropic function of hypophysis are of importance for obstetric and gynecological practice.