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Choroidal thickness in keratoconus.

Burak Bilgin1, Ayse Sevgi Karadag2

  • 1Department of Ophthalmology, Bahçeşehir University, İstanbul, Turkey. burbilgin@yahoo.com.

International Ophthalmology
|August 22, 2019
PubMed
Summary
This summary is machine-generated.

Choroidal thickness is increased in keratoconus patients, suggesting it may serve as a new clinical marker for disease activity. This finding aids in understanding and managing this progressive eye condition.

Keywords:
Choroidal thicknessCorneal thicknessKeratoconusKeratometryOptical coherence tomography

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Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Choroidal Imaging

Background:

  • Keratoconus is an ectatic corneal disease causing progressive thinning, steepening, irregular astigmatism, and vision loss.
  • Understanding choroidal thickness in keratoconus may offer insights into disease mechanisms and management.
  • Choroidal thickness is a potential biomarker for keratoconus disease activity.

Purpose of the Study:

  • To determine choroidal thickness in patients with keratoconus.
  • To compare choroidal thickness between keratoconus patients and age-matched healthy controls.
  • To investigate choroidal thickness as a potential marker for keratoconus disease activity.

Main Methods:

  • Prospective study involving 80 keratoconus patients and 80 healthy controls.
  • Keratometry and thinnest corneal thickness were measured.
  • Choroidal thickness was assessed using Spectralis Optical Coherence Tomography (OCT) with enhanced depth imaging.

Main Results:

  • Mean choroidal thickness was significantly higher in keratoconus patients (363.9 ± 59.8 microns) compared to healthy subjects (328.4 ± 67.2 microns).
  • No statistically significant correlation was found between choroidal thickness and thinnest corneal thickness in keratoconus patients.
  • P-value for choroidal thickness difference was < 0.000, indicating high significance.

Conclusions:

  • Choroidal thickness is elevated in individuals with keratoconus.
  • Increased choroidal thickness may represent a novel clinical marker for assessing keratoconus disease activity.
  • Further research can explore the clinical utility of choroidal thickness measurements in keratoconus management.