Related Experiment Video
Updated: Jan 20, 2026

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks
Published on: December 2, 2022
Putative mechanism for anticancer properties of Ag-PP (NPs) extract
Masoud Homayouni-Tabrizi1, Mozhgan Soltani2, Ehsan Karimi2
1Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran. mhomayouni6@gmail.com.
Abstract:
One of the most important challenges in treating cancer is the invasion and the angiogenesis of cancer cells. The synthesis of green nanoparticles (NPs) and their use in therapeutic fields is one of the most effective methods with minimal side effects in cancer treatment. In this study, cytotoxic and anti-angiogenic effects of silver NPs (AgNPs) coated with palm pollen extract [Ag-PP(NPs)] were evaluated. For this purpose, the cells were treated with NPs and then were subjected to trypan blue testing (48 h). Then, the cancer invasion was evaluated by the scratch procedure and the expressions of the vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) genes were estimated using real-time PCR assay. Also, the angiogenesis effect of the NPs was investigated with chick chorioallantoic membrane (CAM) assay. The Ag-PP(NPs) induced cytotoxicity on MCF7 cells. The findings also showed that Ag-PP(NPs) inhibit invasive cancer cells and reduce the expression of VEGF and VEGF-R and significantly reduced the number and vessels lengths and the lengths and weights of the embryos in CAM assay. Ag-PP(NPs) with the induction of cytotoxic effects, metastatic inhibition and anti-angiogenesis properties should be considered as an appropriate option for treatment of cancer.
Related Concept Videos
Physical and Chemical Properties of Matter
Properties of Transition Metals
The Quantum-Mechanical Model of an Atom
Reaction Mechanisms
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
Convolution Properties I
The commutative property reveals that the input and the impulse response of an LTI (Linear Time-Invariant) system can be interchanged without affecting the output:
Properties of DTFT II
The frequency differentiation property is illustrated by considering a DTFT pair and differentiating both sides with respect to ω.

