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Updated: Jan 20, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks
Published on: September 5, 2014
Facile synthesis of metal-organic framework-derived SiW12@Co3O4 and its peroxidase-like activity in colorimetric
Wei Shi1, Shuang E1, Meng-Meng Wang1
1Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Box332, Shenyang 110819, China. chenml@mail.neu.edu.cn jianhuajrz@mail.neu.edu.cn.
Abstract:
Over the past few years, artificial enzymes have attracted enormous attention due to their high stabilities and cost-effective productions. In this work, metal-organic framework-derived SiW12@Co3O4 was synthesized in large quantities by stirring the mixture at ambient temperature and calcination. The obtained SiW12@Co3O4 exhibited a highly inherent peroxidase-like activity and excellent stability. Kinetic studies demonstrated that the synthesized SiW12@Co3O4 had a strong binding affinity to 3,3',5,5'-tetramethylbenzidine (TMB), stronger than HRP had. Specifically, the peroxidase-like activity of SiW12@Co3O4 in an aqueous solution was well maintained after incubation at an elevated temperature, at an extreme pH and for a long time. A SiW12@Co3O4-based method was further developed for H2O2 and one-pot glucose detection with good sensitivity and reliability. The facile synthesis approach is expected to facilitate the practical use of metal-organic frameworks and their derivatives as enzyme mimics in the future.
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