Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbes in Beverage Production01:25

Microbes in Beverage Production

Alcoholic beverages such as wine, beer, and spirits are the products of microbial fermentation processes that transform simple sugars into ethanol and a wide array of complex flavor compounds. These transformations rely on the metabolic activities of specific yeasts and bacteria, which are selected and controlled to yield the desired beverage characteristics.Wine Fermentation and MaturationWine production begins with the crushing of grapes to release juice and pulp, forming a must that is...
Bioreactor Controls-III01:22

Bioreactor Controls-III

Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
Batch vs Continuous Culture01:14

Batch vs Continuous Culture

Fermentation is a foundational biotechnological process used to produce pharmaceuticals, biofuels, enzymes, and food additives. Among industrial strategies, batch and continuous fermentation are the two most widely applied. Although both rely on microbial conversion of substrates into desired products, they differ markedly in operation, productivity, and suitability for specific applications.Batch fermentation occurs in a closed system in which nutrient media and inoculum are added at the...
Production of Alcohol01:27

Production of Alcohol

Continuous fermentation is a key strategy in industrial ethanol production, particularly when efficiency, scalability, and high yields are essential. This approach allows for uninterrupted operation and optimized resource utilization. The primary feedstock, corn starch, undergoes enzymatic hydrolysis facilitated by α-amylase and glucoamylase. These enzymes break down the starch into fermentable sugars such as glucose, which are readily assimilated by fermentative microorganisms.Fermentation...
Downstream Processing01:29

Downstream Processing

Downstream processing begins once fermentation is complete and involves a series of steps to recover and purify products such as acids, vitamins, antibiotics, or proteins.Cell HarvestingFor example, for intracellular protein-based products, the first step is harvesting the cells. This is typically achieved using centrifugation or filtration to separate the cells from the liquid phase.Cell Disruption for Intracellular ProductsIf the target product is intracellular, the harvested cells must be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of Harvesting and Seasonal Variability on the Physicochemical and Antioxidant Properties of Native Bee <i>(Tetragonisca fiebrigi)</i> Honey from Bolivia's Tropical Dry Forests.

Molecules (Basel, Switzerland)·2026
Same author

Impact of Pre-Treatment Strategies on Enzymatic Hydrolysis of Alternative Protein Sources: Case Study for Black Soldier Fly Larvae.

Molecules (Basel, Switzerland)·2026
Same author

Valorization of <i>Pterospartum tridentatum</i> (Carqueja) Stems: Influence of Extraction Methods on Phenolic Composition, Antioxidant Capacity, and Functional Bioactivity.

Foods (Basel, Switzerland)·2026
Same author

Gut Microbiota Modulation by Carboxymethyl Cellulose and Carrageenan: Current Evidence and Health Implications.

Foods (Basel, Switzerland)·2026
Same author

Processing and Valorization of Wheat Bran, Germ and Their Fractions: An Evidence-Graded Review of Composition, Technologies and Applications.

Foods (Basel, Switzerland)·2026
Same author

Upcycled Orange Peel Ingredients for Gastrointestinal and Cardiometabolic Health: A Scoping Review and Market Perspectives.

Nutrients·2026

Related Experiment Video

Updated: Jun 28, 2026

Methods for Facilitating Microbial Growth on Pulp Mill Waste Streams and Characterization of the Biodegradation Potential of Cultured Microbes
16:33

Methods for Facilitating Microbial Growth on Pulp Mill Waste Streams and Characterization of the Biodegradation Potential of Cultured Microbes

Published on: December 12, 2013

Current extraction techniques towards bioactive compounds from brewer's spent grain - A review.

T Bonifácio-Lopes1,2, José A Teixeira1, Manuela Pintado1

  • 1CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Porto, Portugal.

Critical Reviews in Food Science and Nutrition
|August 22, 2019
PubMed
Summary

Brewer's spent grain (BSG), a brewing by-product rich in bioactive compounds, offers potential for food applications beyond animal feed. This review explores extraction methods and highlights the need for new techniques and uses for BSG.

Keywords:
Bioactive compoundsbrewer’s spent grainchemical compositionextraction techniques

More Related Videos

Techniques for the Evolution of Robust Pentose-fermenting Yeast for Bioconversion of Lignocellulose to Ethanol
14:53

Techniques for the Evolution of Robust Pentose-fermenting Yeast for Bioconversion of Lignocellulose to Ethanol

Published on: October 24, 2016

Untargeted Liquid Chromatography-Mass Spectrometry-Based Metabolomics Analysis of Wheat Grain
07:10

Untargeted Liquid Chromatography-Mass Spectrometry-Based Metabolomics Analysis of Wheat Grain

Published on: March 13, 2020

Related Experiment Videos

Last Updated: Jun 28, 2026

Methods for Facilitating Microbial Growth on Pulp Mill Waste Streams and Characterization of the Biodegradation Potential of Cultured Microbes
16:33

Methods for Facilitating Microbial Growth on Pulp Mill Waste Streams and Characterization of the Biodegradation Potential of Cultured Microbes

Published on: December 12, 2013

Techniques for the Evolution of Robust Pentose-fermenting Yeast for Bioconversion of Lignocellulose to Ethanol
14:53

Techniques for the Evolution of Robust Pentose-fermenting Yeast for Bioconversion of Lignocellulose to Ethanol

Published on: October 24, 2016

Untargeted Liquid Chromatography-Mass Spectrometry-Based Metabolomics Analysis of Wheat Grain
07:10

Untargeted Liquid Chromatography-Mass Spectrometry-Based Metabolomics Analysis of Wheat Grain

Published on: March 13, 2020

Area of Science:

  • Food Science
  • Biotechnology
  • Chemical Engineering

Background:

  • Brewer's spent grain (BSG) is a major brewing industry by-product.
  • BSG is abundant in valuable bioactive compounds like phenolic acids, dietary fiber, and proteins.
  • Currently, BSG is primarily used as animal feed, but its nutritional profile suggests broader food applications.

Purpose of the Study:

  • To review the composition and applications of BSG.
  • To analyze the advantages and limitations of various BSG extraction methods.
  • To identify the need for novel extraction techniques and applications for BSG.

Main Methods:

  • Literature review of BSG composition, applications, and extraction techniques.
  • Analysis of established extraction methods including supercritical CO2, autohydrolysis, alkaline hydrolysis, solvent extraction, ultrasound-assisted extraction, dilute acid hydrolysis, enzymatic hydrolysis, and microwave-assisted extraction.
  • Evaluation of current research on BSG bioactive compound extraction.

Main Results:

  • BSG is a rich source of bioactive compounds with potential for valorization.
  • Multiple extraction methods exist, each with specific advantages and drawbacks.
  • Optimizing extraction yields and exploring new applications are crucial for BSG utilization.

Conclusions:

  • Re-utilizing agro-industrial by-products like BSG can create added-value products.
  • Effective extraction of bioactive compounds from BSG requires further research into advanced techniques.
  • Developing innovative applications for BSG is essential for sustainable resource management.