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Fatal hepatic necrosis associated with multiple anticonvulsant therapy
D W Smith1, G J Cullity, E P Silberstein
1Department of Anatomical Pathology, Princess Margaret Hospital for Children, WA, Australia.
Australian and New Zealand Journal of Medicine
|June 1, 1988
Summary
Multiple anticonvulsant therapies may cause fatal hepatic necrosis in children. An idiosyncratic metabolic reaction is suspected, potentially triggered by metabolic changes from prolonged seizures, rather than specific drug toxicity.
Area of Science:
- Pediatric Hepatology
- Clinical Toxicology
- Neuropharmacology
Background:
- Hepatic necrosis is a severe liver injury.
- Anticonvulsant medications are widely used in pediatric epilepsy management.
- The potential for drug-induced liver injury from anticonvulsants necessitates ongoing investigation.