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Dietary natural flavonoids treating cancer by targeting aryl hydrocarbon receptor

Tian Yang1, Ya-Long Feng1, Lin Chen1

  • 1Faculty of Life Science & Medicine, Northwest University, Xi'an, China.

Critical Reviews in Toxicology
|August 22, 2019
PubMed

Insights

Dietary flavonoids activate the aryl hydrocarbon receptor (AhR), influencing cancer. This review explores AhR

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Pharmacology

Background:

  • The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor increasingly recognized for its role in cancer.
  • AhR signaling influences critical cellular processes such as proliferation, apoptosis, and immune metabolism, impacting tumor progression.
  • Dietary compounds, particularly flavonoids, are significant natural sources of AhR ligands.

Purpose of the Study:

  • To review the dual role of AhR in cancer therapy.
  • To explore the molecular mechanisms of AhR ligands in cancer.
  • To summarize the potential of dietary flavonoids as AhR ligands for cancer inhibition.

Main Methods:

  • Literature review focusing on AhR's role in tumorigenesis.
  • Analysis of molecular mechanisms of AhR agonists/antagonists in cancer.
  • Examination of dietary flavonoids as natural AhR ligands.

Main Results:

  • AhR plays a complex, often dual, role in cancer development and treatment.
  • Dietary flavonoids represent a major class of natural AhR ligands with potential anti-cancer effects.
  • Understanding AhR ligand mechanisms offers new therapeutic avenues.

Conclusions:

  • AhR targeted therapy holds promise for novel cancer treatments.
  • Dietary flavonoids are promising candidates for AhR-mediated cancer inhibition.
  • Further clinical research is needed to address limitations of dietary flavonoids in cancer therapy.
Keywords:
Aryl hydrocarbon receptorcancerflavonoidsligandnatural products

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