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Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice
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Cognitive Training Reorganizes Network Modularity in Traumatic Brain Injury.
Kihwan Han1, Sandra B Chapman1, Daniel C Krawczyk1,2
1The University of Texas at Dallas, TX, USA.
Neurorehabilitation and Neural Repair
|August 23, 2019
Summary
Cognitive training in traumatic brain injury (TBI) reorganizes whole-brain networks, improving global and local brain efficiency. This neuroplasticity, measured by graph theory, correlates with cognitive performance, suggesting a marker for training effectiveness.
Area of Science:
- Neuroscience
- Cognitive Science
- Medical Imaging
Background:
- Traumatic brain injury (TBI) often disrupts neural systems, with graph theory emerging as a tool to study these changes.
- Understanding neuroplasticity and brain network reorganization following cognitive training in TBI patients remains a critical research area.
Purpose of the Study:
- To investigate training-induced neuroplasticity in the whole-brain network of individuals with TBI.
- To utilize resting-state functional connectivity and graph theory to analyze brain network changes after cognitive training.
Main Methods:
- Randomized controlled trial with 64 TBI participants assigned to strategy-based cognitive training or knowledge-based active control for 8 weeks.
- Resting-state functional magnetic resonance imaging (rs-fMRI) acquired pre-training, immediately post-training, and 3 months post-training.
- Graph theory metrics (modularity, participation coefficient, global/local efficiency) analyzed longitudinally using false discovery rate correction.
Main Results:
- Strategy-based cognitive training led to reduced modularity and increased participation coefficient, global efficiency, and local efficiency compared to the control group.
- Brain-behavior analysis showed correlations between participation coefficient, global efficiency, and trail-making test scores within the strategy-based training group.
- Significant changes in brain network organization were observed over time and persisted for 3 months post-training.
Conclusions:
- Cognitive training effectively reorganizes modular brain networks in individuals with TBI.
- Graph-theoretic approaches show promise for identifying brain-based biomarkers of cognitive training efficacy in TBI recovery.
- Findings highlight the potential of targeted cognitive interventions to promote neuroplasticity after TBI.
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