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08:27
Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
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Treating murine inflammatory diseases with an anti-erythrocyte antibody
Andrew R Crow1,2,3, Rick Kapur1,2,3,4,5, Sandra Koernig6
1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.
Science Translational Medicine
|August 23, 2019
Summary
This study reveals that the inflammatory antibody Ter119 resolves inflammatory diseases by altering monocyte behavior. This novel approach offers broad therapeutic potential for conditions like arthritis.
Area of Science:
- Immunology
- Inflammation Research
- Hematology
Background:
- Autoimmune and inflammatory diseases are typically managed with immune suppression.
- A novel strategy explores utilizing inflammatory stimuli to resolve disease.
Purpose of the Study:
- To investigate the therapeutic potential of the erythrocyte-specific antibody Ter119 in inflammatory conditions.
- To elucidate the mechanisms by which Ter119 impacts the monocyte cellular landscape and disease resolution.
Main Methods:
- Administration of Ter119 antibody in mouse models of arthritis (K/BxN serum transfer, collagen antibody-induced arthritis, collagen-induced arthritis).
- Analysis of monocyte percentages, Fcγ receptor expression, plasma chemokines (CCL2, CCL5, CXCL9, CXCL10, CCL11), synovial fluid, and acute lung injury markers.
Main Results:
- Ter119 demonstrated therapeutic effects, reversing clinical disease progression in arthritis models.
- It normalized monocyte Fcγ receptor II/III expression and modulated chemokine profiles.
- Ter119 attenuated synovial inflammation and accelerated recovery in acute lung injury.
Conclusions:
- The anti-erythrocyte antibody Ter119 triggers potent anti-inflammatory effects by remodeling the monocyte landscape.
- This approach presents a promising therapeutic strategy for diverse inflammatory diseases.
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