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Clinical Features and Histopathology of Cardiac Sarcoidosis with Refractory Heart Failure: An Autopsy Case

Fumio Terasaki1,2, Hiroko Kuwabara3, Yoshihiro Takeda2

  • 1Medical Education Center, Osaka Medical College, Japan.

Internal Medicine (Tokyo, Japan)
|August 23, 2019
PubMed

Insights

Implantable cardioverter defibrillator and cardiac resynchronization therapy improve cardiac sarcoidosis outcomes. However, advanced heart failure still poses a poor prognosis, as seen in this patient case.

Area of Science:

  • Cardiology
  • Immunology
  • Pathology

Background:

  • Cardiac sarcoidosis is an inflammatory condition affecting the heart.
  • Implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy (CRT) have improved patient survival.
  • Despite advancements, advanced cardiac dysfunction and heart failure remain challenging.

Observation:

  • This report details the clinical course of a patient with cardiac sarcoidosis.
  • The patient experienced long-term refractory heart failure.
  • Autopsy examination provided histopathological findings of the heart.

Findings:

  • While ICD and CRT offer benefits, they do not guarantee survival in advanced stages.
  • Refractory heart failure in cardiac sarcoidosis indicates a persistent poor prognosis.
  • Histopathological analysis revealed specific cardiac changes in this severe case.

Implications:

  • Further research is needed to improve outcomes for patients with advanced cardiac sarcoidosis and heart failure.
  • Understanding the histopathology of refractory cases is crucial for developing new therapeutic strategies.
  • This case highlights the limitations of current treatments in end-stage disease.

Keywords:
dilated cardiomyopathyheart failurepathologyprognosissarcoidosis

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