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Updated: Jan 20, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
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Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

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Role of some epigenetic factors in DNA damage response pathway

Mrinalini Tiwari1, Suhel Parvez2, Paban K Agrawala1

  • 1Department of Radiation Genetics and Epigenetics, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Road, Timarpur, Delhi 110054 India.

AIMS Genetics
|August 23, 2019
PubMed

Insights

This review covers the DNA damage response pathway and epigenetic mechanisms, focusing on histone modifications that impact DNA repair. It also briefly discusses histone deacetylase inhibitors as potential radiomitigators.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Genetics

Background:

  • DNA damage triggers a complex response pathway involving numerous proteins.
  • Epigenetic mechanisms, particularly histone modifications, play a crucial role in regulating this pathway.
  • Chromatin's compact structure can impede efficient DNA repair, highlighting the importance of structural alterations.

Purpose of the Study:

  • To review the DNA damage response (DDR) pathway.
  • To elucidate the involvement of epigenetic mechanisms in the DDR pathway.
  • To discuss the impact of histone modifications on chromatin structure and DNA repair.

Main Methods:

  • Literature review of DNA damage response pathways.
  • Analysis of epigenetic mechanisms, focusing on histone modifications.
  • Evaluation of histone deacetylase inhibitors as radiomitigators.

Main Results:

  • Histone modifications are integral to the DNA damage response.
  • Chromatin structural changes mediated by histone modifications influence DNA repair efficiency.
  • Histone deacetylase inhibitors show potential as radiomitigators.

Conclusions:

  • Epigenetic regulation, especially histone modifications, is critical for effective DNA repair.
  • Targeting histone deacetylases may offer a strategy to enhance DNA repair and mitigate radiation damage.
Keywords:
DNA damage responseepigeneticshistone acetylationradiomitigation

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