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Related Concept Videos

Centrioles and Centrosomes01:13

Centrioles and Centrosomes

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Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
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Centrosome Duplication02:25

Centrosome Duplication

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The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
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RACE - Rapid Amplification of cDNA Ends02:35

RACE - Rapid Amplification of cDNA Ends

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Rapid Amplification of cDNA Ends, or RACE, is one of the most effective methods to obtain a full-length cDNA from an mRNA sequence between a known internal region to the unknown sequence at the 5’ or 3’ end. The unknown region is cloned in the cDNA by a gene-specific primer that binds the known end, and a hybrid primer that attaches a predefined anchor sequence to the unknown end of the cDNA. The sequence in between is amplified by PCR with an anchor primer and a gene-specific...
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Meiosis II01:57

Meiosis II

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Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
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Interphase00:54

Interphase

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The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
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Meiosis I01:49

Meiosis I

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Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...
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Related Experiment Video

Updated: Jan 20, 2026

Imaging Centrosomes in Fly Testes
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Imaging Centrosomes in Fly Testes

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Centrosome Amplification and Tumorigenesis: Cause or Effect?

Arunabha Bose1,2, Sorab N Dalal3,4

  • 1KS215, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra, India.

Results and Problems in Cell Differentiation
|August 23, 2019
PubMed
Summary

Centrosome amplification, an increase in centrosome number, is common in tumors. This review explores how centrosome amplification drives tumor initiation and progression by examining regulatory proteins.

Keywords:
AneuploidyCentrioleCentrosomeChromosomal instability

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Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
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Immuno-fluorescent Labeling of Microtubules and Centrosomal Proteins in Ex Vivo Intestinal Tissue and 3D In Vitro Intestinal Organoids

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Immuno-fluorescent Labeling of Microtubules and Centrosomal Proteins in Ex Vivo Intestinal Tissue and 3D In Vitro Intestinal Organoids
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Area of Science:

  • Cell Biology
  • Cancer Biology
  • Molecular Oncology

Background:

  • Centrosome amplification is observed in numerous cancer types.
  • Its role in tumor initiation and progression is under investigation.
  • Understanding these mechanisms is crucial for cancer therapy.

Purpose of the Study:

  • To elucidate the mechanisms linking centrosome amplification to tumor progression.
  • To explore how altered centrosome numbers influence cancer development.
  • To review the function of proteins regulating centrosome number in tumorigenesis.

Main Methods:

  • Literature review of studies on centrosome amplification and cancer.
  • Analysis of molecular pathways involving centrosome regulatory proteins.
  • Examination of experimental evidence linking centrosome number to tumor phenotypes.

Main Results:

  • Increased centrosome number can promote or inhibit tumor progression depending on context.
  • Specific proteins regulating centrosome duplication are key drivers of tumorigenesis.
  • Aberrant centrosome numbers contribute to genomic instability in cancer cells.

Conclusions:

  • Centrosome amplification is a significant factor in cancer development.
  • Targeting proteins that control centrosome number presents a potential therapeutic strategy.
  • Further research is needed to fully understand the complex role of centrosomes in cancer.