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Assessment of Motor Balance and Coordination in Mice using the Balance Beam
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[Statins and new-onset diabetes : benefit-risk balance]

Caroline Wallemacq1

  • 1Service de diabétologie, maladies métaboliques et nutrition, Département de médecine interne, Centre hospitalier universitaire de Liège, 4000 Liège, Belgique.

Revue Medicale Suisse
|August 23, 2019
PubMed

Insights

Statins, widely used for heart health, may increase the risk of developing type 2 diabetes (T2D). However, their cardiovascular benefits outweigh this risk, especially for high-risk individuals.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Statins are primary agents for cardiovascular disease prevention.
  • Clinical trials and observational studies indicate an elevated risk of type 2 diabetes (T2D) associated with statin use.
  • The precise molecular mechanisms underlying this association are not fully elucidated.

Purpose of the Study:

  • To summarize the evidence regarding the increased risk of type 2 diabetes (T2D) in patients treated with statins.
  • To discuss the factors influencing this risk and the clinical implications for patient management.

Main Methods:

  • Review of randomized clinical trials.
  • Analysis of genetic Mendelian randomization studies.
  • Examination of observational cohort data.

Main Results:

  • Consistent evidence demonstrates an increased incidence of T2D with statin therapy.
  • Higher statin doses and pre-existing risk factors (e.g., metabolic syndrome, prediabetes) amplify T2D risk.
  • The benefits of statins in cardiovascular prevention significantly exceed the associated diabetes risk.

Conclusions:

  • Statin therapy remains crucial for cardiovascular risk reduction in high-risk populations.
  • Glycemic monitoring and lifestyle modifications are recommended for individuals at increased risk of T2D while on statins.

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