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Aggregation-Induced Emission Luminogens for Activity-Based Sensing.

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Aggregation-induced emission (AIE) sensors offer a solution to aggregation-caused quenching (ACQ) in activity-based sensing (ABS). This approach enhances fluorescent detection of various targets, showing great potential for bioprobing and medical innovations.

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biotechnology

Background:

  • Fluorescent sensing offers high sensitivity and rapid detection for biological processes.
  • Activity-based sensing (ABS) relies on molecular reactivity, providing specificity and sensitivity.
  • Conventional fluorogens suffer from aggregation-caused quenching (ACQ), limiting applications.

Purpose of the Study:

  • To introduce aggregation-induced emission (AIE) as a solution to ACQ in ABS.
  • To highlight recent breakthroughs and trends in AIEgen-involved ABS.
  • To showcase the application of AIE-ABS for detecting various targets relevant to human health.

Main Methods:

  • Utilizing AIE-active luminogens (AIEgens) as alternatives to ACQ fluorogens in ABS.
  • Developing AIEgen-involved ABS strategies based on various chemical reactions (hydrolysis, dephosphorylation, etc.).
  • Investigating AIE-ABS for detecting ions, small molecules, biomacromolecules, and microenvironments.

Main Results:

  • AIEgens overcome ACQ limitations, offering high photobleaching resistance and signal-to-noise ratio.
  • AIE-ABS demonstrates 'turn-on' fluorescence signaling, sometimes with color changes and solubility variations.
  • Successful detection of diverse analytes with high selectivity, reliability, and signal contrast.

Conclusions:

  • AIEgen-involved ABS integrates the advantages of AIE and ABS for advanced fluorescent sensing.
  • This strategy shows excellent biocompatibility and high potential for bioprobing and medical diagnostics.
  • AIE-ABS represents a promising innovation in sensing technology with broad applicability.