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Updated: Jan 20, 2026

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Synthesis and Antibacterial Evaluation of Mannich Bases Derived from 1,2,4-Triazole
Agata Paneth1, Nazar Trotsko1, Łukasz Popiołek1
1Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4 A Chodzki Street, 20-093, Lublin, Poland.
Abstract:
The series of novel Mannich bases were synthesized and evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. The results showed that all compounds were less active than the drugs used as reference, but some of them had moderate potency against Staphylococcus epidermidis ATCC 12228 and Bacillus subtilis ATCC 6633. The presence of a phenyl ring in the position 4 of piperazine seems to be necessary for antibacterial activity in this class of compounds.
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