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Thrazarine, a new antitumor antibiotic. II. Physico-chemical properties and structure determination
A Takahashi1, H Nakamura, D Ikeda
1Institute of Microbial Chemistry, Tokyo, Japan.
The Journal of Antibiotics
|November 1, 1988
Abstract:
A new antitumor antibiotic thrazarine was soluble in water and positive to anisaldehyde-sulfuric acid and ninhydrin color reactions. The absolute structure of thrazarine was determined to be O-[3R)-2-diazo-3-hydroxybutyryl)-L-serine by acid hydrolysis, spectroscopic analysis and X-ray crystallographic analysis. Structurally, thrazarine was a new member of azaserine group antibiotics.