Cardiac Tissue Engineering as Use Case to Connect Biomedical Research Laboratories to an Emerging Global Data...

Area of Science:

• Biomedical Engineering
• Pharmacology
• Toxicology

Background:

• Cardiac tissue engineering and experimental applications are key technologies at the Institute of Pharmacology and Toxicology in Göttingen.
• Current data capture and documentation practices in academic research labs, including this institute, can be improved with modern digital research methods.

Purpose of the Study:

• To propose and prototypically deploy a data management system concept for enhancing lab processes.
• To enable traceability of assets and reproducibility of assays and results within a research setting.
• To lay the foundation for increased automation in laboratory processes through a comprehensive information system infrastructure.

Main Methods:

• Development of a data management system concept.
• Prototypical deployment of the system integrating existing electronic lab notebooks and experiment result databases.
• Creation of a custom portal and integration component to connect disparate data sources.
• Exploration of connecting routine experimental work to a universal data infrastructure.

Main Results:

• A prototypically deployed data management system enabling asset traceability.
• Improved reproducibility of published assays and results.
• Integration of existing electronic lab notebook and experiment result databases with a new research data management system.
• Demonstration of a custom portal and integration component for data connectivity.

Conclusions:

• The proposed data management system concept and its prototype provide a foundation for advancing digital research methods in a biomedical setting.
• The developed integration tools facilitate the connection of routine experimental work to a universal data infrastructure.
• Implementing such systems is crucial for improving data integrity, reproducibility, and automation in research laboratories.